Last edited by Gardara
Sunday, May 17, 2020 | History

3 edition of Chemistry and biological actions of 4-nitroquinoline 1-oxide. found in the catalog.

Chemistry and biological actions of 4-nitroquinoline 1-oxide.

Chemistry and biological actions of 4-nitroquinoline 1-oxide.

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  • 19 Currently reading

Published by Springer-Verlag in Berlin, New York .
Written in English

    Subjects:
  • Nitroquinoline oxide -- Physiological effect,
  • Carcinogens

  • Edition Notes

    Bibliography: p. [85]-98.

    StatementEdited by H. Endo, T. Ono [and] T. Sugimura.
    SeriesRecent results in cancer research,, 34
    ContributionsEndo, Hideya, 1925- ed., Ono, Tetsuo, ed., Sugimura, Takashi, ed.
    Classifications
    LC ClassificationsRC261 .R35 no. 34
    The Physical Object
    Pagination101 p.
    Number of Pages101
    ID Numbers
    Open LibraryOL4913892M
    ISBN 100387052305
    LC Control Number76129622

    Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown Reviews: 1.   Abstract. We investigated the effects of bexarotene (a retinoid X receptor agonist), CD (a retinoic acid receptor γ selective agonist), and the combination of these two drugs for the prevention of oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma previously generated in our .

    Comprehensive natural products II chemistry and biology (1st ed.). Oxford: Elsevier Science. ISBN CS1 maint: extra text: authors list ; Sugimura, edited by Hideya Endo, Tetsuo Ono, Takashi (). Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide. Berlin, Heidelberg: Springer Berlin Heidelberg. ISBN Originally published in , this volume looks in depth at the carcinogenic properties of N-nitroso compounds. These compounds occur widely in smoked foods and in meat and fish cured with nitrates; they are also formed in some industrial processes and in Format: Paperback.

    Here, we report an assay for estimating the toxicity of chemical substances by visualizing transcription in mammalian cells using nucleotide analog 5-ethynyluridine (EU) and its click chemistry reaction. Ultraviolet light and representative chemical substances (camptothecin, 4-nitroquinolineoxide, mitomycin C, and cisplatin, but not. Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown.


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Chemistry and biological actions of 4-nitroquinoline 1-oxide Download PDF EPUB FB2

During the last decade a considerable body of knowledge has come into existence concerning a class of carcinogenic molecules chiefly represented by 4-nitroquinoline i-oxide. Original papers on this subject are numerous and widely scattered over many branches of science; it was felt that these papers should be reviewed and the knowledge brought.

Chemistry and biological actions of 4-nitroquinoline 1-oxide. Berlin, New York, Springer-Verlag, (OCoLC) Document Type: Book: All Authors / Contributors: H Endo. Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide During the last decade a considerable body of knowledge has come into existence concerning a class of carcinogenic molecules chiefly represented by 4-nitroquinoline i-oxide.

Get this from a library. Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide. [Hideya Endo; Tetsuo Ono; Takashi Sugimura] -- During the last decade a considerable body of knowledge has come into existence concerning a class of carcinogenic molecules chiefly represented by 4-nitroquinoline i-oxide.

Original papers on this. A mono- graphic review of studies on this compound entitled "Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide" by Endo et al. () has been published.

Therefore, the present review principally aims to cover more recent reports on this by: M~atio~ Research, 22 (I) ,0 Elsevier Scientific Publishing Company, Amsterdam Printed in The Netherlands 8I SHORT COMMUNICATIONS 4-Nitroquinoline 1-oxide-induced deletion mutations in Escherichia coli strains with different DNA repair capacities 4NQO is one of the most widely used chemical carcinogens1.

Cite this chapter as: Kawazoe Y. () Chemical Properties. In: Endo H., Ono T., Sugimura T. (eds) Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide. 4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects.

Packaging 1, 5 g in poly bottle mg in poly bottle Biochem/physiol Actions Skin and lung tumor initiator under experimental conditions. Search results for 4-Nitroquinoline 1-oxide at Sigma-Aldrich.

Compare Products: Select up to 4 products. *Please select more than one item to compare. 4NQO is known to mimic the biological effects of ultraviolet light on various organisms.

Both 4NQO and its reduced metabolite 4-hydroxyaminoquinoline 1-oxide (4HAQO) bind covalently to cellular macromolecules such as nucleic acids and proteins. 4NQO has been shown to trap topoisomerase I cleavage complexes. It may also induce DNA damage through the production of reactive oxygen species thought to arise from enzymatic reduction of its nitro.

These compounds were assayed with other mutagens, 4-nitroquinoline 1-oxide (4NQO) and N-methyl-N‘-nitro-N-nitrosoguanidine (MNNG). In addition, compounds 1−4 were assayed with 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and aflatoxin B 1 (AfB1), which requires liver metabolizing enzymes.

These compounds showed suppresssive effects. Interaction of 4-Nitroquinolineoxide with Indole Derivatives and Some Related Biomolecules: A Study with Magnetic Field. The Journal of Physical Chemistry B(17), DOI: /jpl.

The Hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible information in CAMEO Chemicals comes from a variety of data sources.

Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide. Title Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide. This we have attempted to do in this monograph. We have been fortunate in securing the cooperation of several colleagues who have contributed chapters, each dealing with one aspect of the subject.

Inhibition of 4-nitroquinolineoxide (4-NQO) genotoxicity by a probiotic strain of Lactobacillus rhamnosus (IMC) was assessed by the prokaryotic short-term bioassay SOS-Chromotest, using.

When cells are transformed by 3-methylcholanthrene7, 4-nitroquinolineoxide (4NQO)8, or X irradiation9–11, division is necessary soon after treatment to fix the transformation: if treated.

A number of chemical carcinogens like coal tar, 20 methyl cholanthrene (20MC), 9,dimethyl-1,2-benzanthracene (DMBA) and 4-nitroquinolineoxide (4NQO) have been used in experimental oral.

Author(s): Endo,Hideya; Ono,Tetsuo; Sugimura,Takashi Title(s): Chemistry and biological actions of 4-nitroquinoline 1-oxide/ edited by H. Endo, T. Ono [and] T. J.S Harvey and J.M Parry, The analysis of DNA adduct formation, removal and persistence in the common mussel Mytilus edulis exposed to 4-nitroquinoline 1-oxide, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,1, (31), ().

4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA adducts, N -(deoxyguanosinyl)-4AQO, 3-(desoxyguanosin- N 2 -yl)-4AQO and 3-(deoxyadenosin- N 6.

Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide. H. Endo. $ Engineering Mechanics - Equilibrium of Rigid Bodies for Bahrain Students General Chemistry: Measurements. by Dr. Evelyn J Biluk. Chemistry (Book 1) Share your thoughts Complete your review.The Paperback of the Chemistry of Fungicidal Action by Raymond J.

Lukens at Barnes & Noble. FREE Shipping on $35 or more! Due to COVID, orders may be delayed.Lactobacillus fermentum CQPC08 (LF-CQPC08) is a newly discovered strain of bacteria isolated and identified from traditional pickled vegetables in Sichuan, China.

We used 4-nitroquinoline 1-oxide to establish an experimental tongue cancer mouse model to evaluate the preventive effect of LF-CQPC08 on tongue cancer in vivo. Lactobacillus delbruechii subsp. bulgaricus, is a common commercial.